The College of Science (CS) was established, in accordance with a presidential decree; in 1989. It consists of six departments; Chemistry, Physics, Scientific Laboratories (Chemistry & Physics), Mathematics, Applied Statistics and The General Department. The college aims to achieve the following objectives:-
* Teaching basic and applied natural sciences to students enrolled in the college.
* Serving as a Basic Science Teaching Center for all Sudan University of Science and Technology (SUST) colleges and institutes.
* Conducting research in natural sciences and related fields.
* Providing further and continuous education.
The College is administered by a deanship headed by the dean of the College and located at the University headquarter, in Mugran which can, easily, be reached from any part of Greater Khartoum.